Predictive biomarkers for sacituzumab govitecan efficacy in Trop-2-expressing triple-negative breast cancer

Sacituzumab govitecan (SG) is an antibody-drug conjugate composed of a humanized anti-Trop-2 IgG antibody conjugated via a hydrolysable linker to SN-38, the topoisomerase I-inhibitory active component of irinotecan. We investigated whether Trop-2-expression and homologous recombination repair (HRR)...

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Publicado en:Oncotarget
Autores principales: Cardillo, Thomas M., Rossi, Diane L., Zalath, Maria B., Liu, Donglin, Arrojo, Roberto, Sharkey, Robert M., Chang, Chien-Hsing, Goldenberg, David M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2020
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7597411/
https://ncbi.nlm.nih.gov/pubmed/33196706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.27766
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