Aortic valve sclerosis in mice deficient in endothelial nitric oxide synthase

Risk factors for fibrocalcific aortic valve disease (FCAVD) are associated with systemic decreases in bioavailability of endothelium-derived nitric oxide (EDNO). In patients with bicuspid aortic valve (BAV), vascular expression of endothelial nitric oxide synthase (eNOS) is decreased, and eNOS(−/−)...

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Main Authors: El Accaoui, Ramzi N., Gould, Sarah T., Hajj, Georges P., Chu, Yi, Davis, Melissa K., Kraft, Diane C., Lund, Donald D., Brooks, Robert M., Doshi, Hardik, Zimmerman, Kathy A., Kutschke, William, Anseth, Kristi S., Heistad, Donald D., Weiss, Robert M.
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2014
Fag:
Vascular Biology and Microcirculation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010666/
https://ncbi.nlm.nih.gov/pubmed/24610917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00392.2013
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