Aortic valve sclerosis in mice deficient in endothelial nitric oxide synthase

Risk factors for fibrocalcific aortic valve disease (FCAVD) are associated with systemic decreases in bioavailability of endothelium-derived nitric oxide (EDNO). In patients with bicuspid aortic valve (BAV), vascular expression of endothelial nitric oxide synthase (eNOS) is decreased, and eNOS(−/−)...

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Auteurs principaux: El Accaoui, Ramzi N., Gould, Sarah T., Hajj, Georges P., Chu, Yi, Davis, Melissa K., Kraft, Diane C., Lund, Donald D., Brooks, Robert M., Doshi, Hardik, Zimmerman, Kathy A., Kutschke, William, Anseth, Kristi S., Heistad, Donald D., Weiss, Robert M.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2014
Sujets:
Vascular Biology and Microcirculation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010666/
https://ncbi.nlm.nih.gov/pubmed/24610917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00392.2013
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