A Structural and Energetic Model for the Slow-Onset Inhibition of the Mycobacterium tuberculosis Enoyl-ACP Reductase InhA

[Image: see text] Slow-onset enzyme inhibitors are of great interest for drug discovery programs since the slow dissociation of the inhibitor from the drug–target complex results in sustained target occupancy leading to improved pharmacodynamics. However, the structural basis for slow-onset inhibiti...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Li, Huei-Jiun, Lai, Cheng-Tsung, Pan, Pan, Yu, Weixuan, Liu, Nina, Bommineni, Gopal R., Garcia-Diaz, Miguel, Simmerling, Carlos, Tonge, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4004265/
https://ncbi.nlm.nih.gov/pubmed/24527857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb400896g
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados