Nitric Oxide-Induced Conformational Changes in Soluble Guanylate Cyclase

Soluble guanylate cyclase (sGC) is the primary mediator of nitric oxide (NO) signaling. NO binds the sGC heme cofactor stimulating synthesis of the second messenger cyclic-GMP (cGMP). As the central hub of NO/cGMP signaling pathways, sGC is important in diverse physiological processes such as vasodi...

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Bibliografiske detaljer
Main Authors: Underbakke, Eric S., Iavarone, Anthony T., Chalmers, Michael J., Pascal, Bruce D., Novick, Scott, Griffin, Patrick R., Marletta, Michael A.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4001857/
https://ncbi.nlm.nih.gov/pubmed/24560804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.01.008
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