Higher-order interactions bridge the nitric oxide receptor and catalytic domains of soluble guanylate cyclase

Nitric oxide (NO) signaling pathways mediate diverse physiological functions, including vasodilation and neurotransmission. Soluble guanylate cyclase (sGC), the primary NO receptor, triggers downstream signaling cascades by producing the second messenger cGMP. NO binds the sGC heme cofactor to stimu...

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Bibliographic Details
Main Authors: Underbakke, Eric S., Iavarone, Anthony T., Marletta, Michael A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3637750/
https://ncbi.nlm.nih.gov/pubmed/23572573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1301934110
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