Heme-assisted S-Nitrosation Desensitizes Ferric Soluble Guanylate Cyclase to Nitric Oxide

Nitric oxide (NO) signaling regulates key processes in cardiovascular physiology, specifically vasodilation, platelet aggregation, and leukocyte rolling. Soluble guanylate cyclase (sGC), the mammalian NO sensor, transduces an NO signal into the classical second messenger cyclic GMP (cGMP). NO binds...

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Bibliographic Details
Main Authors: Fernhoff, Nathaniel B., Derbyshire, Emily R., Underbakke, Eric S., Marletta, Michael A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3522300/
https://ncbi.nlm.nih.gov/pubmed/23093402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.393892
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