A molecular basis for nitric oxide sensing by soluble guanylate cyclase
Nitric oxide (NO) functions as a signaling agent by activation of the soluble isoform of guanylate cyclase (sGC), a heterodimeric hemoprotein. NO binds to the heme of sGC and triggers formation of cGMP from GTP. Here we report direct kinetic measurements of the multistep binding of NO to sGC and cor...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1999
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24720/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10611285/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.26.14753 |
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