A molecular basis for nitric oxide sensing by soluble guanylate cyclase

Nitric oxide (NO) functions as a signaling agent by activation of the soluble isoform of guanylate cyclase (sGC), a heterodimeric hemoprotein. NO binds to the heme of sGC and triggers formation of cGMP from GTP. Here we report direct kinetic measurements of the multistep binding of NO to sGC and cor...

Полное описание

Библиографические подробности

Опубликовано в::	Proc Natl Acad Sci U S A
Главные авторы:	Zhao, Yunde, Brandish, Philip E., Ballou, David P., Marletta, Michael A.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	National Academy of Sciences 1999
Предметы:	Biological Sciences
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24720/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10611285/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.26.14753
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