Catalytic consumption of nitric oxide by 12/15- lipoxygenase: Inhibition of monocyte soluble guanylate cyclase activation

12/15-Lipoxygenase (LOX) activity is elevated in vascular diseases associated with impaired nitric oxide ((⋅)NO) bioactivity, such as hypertension and atherosclerosis. In this study, primary porcine monocytes expressing 12/15-LOX, rat A10 smooth muscle cells transfected with murine 12/15-LOX, and pu...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Coffey, Marcus J., Natarajan, Rama, Chumley, Phillip H., Coles, Barbara, Thimmalapura, Pushpa-Rekha, Nowell, Mari, Kühn, Hartmut, Lewis, Malcolm J., Freeman, Bruce A., O'Donnell, Valerie B.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC35458/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11427723/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.141136098
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