Catalytic consumption of nitric oxide by 12/15- lipoxygenase: Inhibition of monocyte soluble guanylate cyclase activation

12/15-Lipoxygenase (LOX) activity is elevated in vascular diseases associated with impaired nitric oxide ((⋅)NO) bioactivity, such as hypertension and atherosclerosis. In this study, primary porcine monocytes expressing 12/15-LOX, rat A10 smooth muscle cells transfected with murine 12/15-LOX, and pu...

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Autors principals: Coffey, Marcus J., Natarajan, Rama, Chumley, Phillip H., Coles, Barbara, Thimmalapura, Pushpa-Rekha, Nowell, Mari, Kühn, Hartmut, Lewis, Malcolm J., Freeman, Bruce A., O'Donnell, Valerie B.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC35458/
https://ncbi.nlm.nih.gov/pubmed/11427723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.141136098
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