Optical Mapping of Sarcoplasmic Reticulum Ca(2+) in the Intact Heart: Ryanodine Receptor Refractoriness During Alternans and Fibrillation

RATIONALE: Sarcoplasmic reticulum (SR) Ca(2+) cycling is key to normal excitation-contraction coupling but may also contribute to pathological cardiac alternans and arrhythmia. OBJECTIVE: To measure intra-SR free [Ca(2+)] ([Ca(2+)](SR)) changes in intact hearts during alternans and ventricular fibri...

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Hauptverfasser: Wang, Lianguo, Myles, Rachel C., De Jesus, Nicole M., Ohlendorf, Alex K.P., Bers, Donald M., Ripplinger, Crystal M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4000583/
https://ncbi.nlm.nih.gov/pubmed/24568740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.114.302505
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