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Decreased inward rectifying K(+) current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart
Heart failure (HF) results in dramatic electrophysiological remodelling, including increased sensitivity of ryanodine receptors (RyRs) and decreased inward rectifying K(+) current (I(K1)), which predisposes HF myocytes to delayed afterdepolarizations and triggered activity. Therefore, we sought to d...
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| Gepubliceerd in: | J Physiol |
|---|---|
| Hoofdauteurs: | , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
BlackWell Publishing Ltd
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4376425/ https://ncbi.nlm.nih.gov/pubmed/25772297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.279638 |
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