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Decreased inward rectifying K(+) current and increased ryanodine receptor sensitivity synergistically contribute to sustained focal arrhythmia in the intact rabbit heart

Heart failure (HF) results in dramatic electrophysiological remodelling, including increased sensitivity of ryanodine receptors (RyRs) and decreased inward rectifying K(+) current (I(K1)), which predisposes HF myocytes to delayed afterdepolarizations and triggered activity. Therefore, we sought to d...

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書目詳細資料
發表在:J Physiol
Main Authors: Myles, Rachel C, Wang, Lianguo, Bers, Donald M, Ripplinger, Crystal M
格式: Artigo
語言:Inglês
出版: BlackWell Publishing Ltd 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376425/
https://ncbi.nlm.nih.gov/pubmed/25772297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.279638
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