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Local beta-adrenergic stimulation overcomes source-sink mismatch to generate focal arrhythmia
RATIONALE: Beta-adrenergic receptor (β-AR) stimulation produces sarcoplasmic reticulum (SR) Ca(2+) overload and delayed after-depolarizations (DADs) in isolated ventricular myocytes. How DADs are synchronized to overcome the source-sink mismatch and produce focal arrhythmia in the intact heart remai...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3396564/ https://ncbi.nlm.nih.gov/pubmed/22539768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.111.262345 |
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