Role of Reduced Sarco-Endoplasmic Reticulum Ca(2+)-ATPase Function on Sarcoplasmic Reticulum Ca(2+) Alternans in the Intact Rabbit Heart

Sarcoplasmic reticulum (SR) Ca(2+) cycling is tightly regulated by ryanodine receptor (RyR) Ca(2+) release and sarco-endoplasmic reticulum Ca(2+)-ATPase (SERCA) Ca(2+) uptake during each excitation–contraction coupling cycle. We previously showed that RyR refractoriness plays a key role in the onset...

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Detalles Bibliográficos
Publicado en:Front Physiol
Main Authors: Wang, Lianguo, Myles, Rachel C., Lee, I-Ju, Bers, Donald M., Ripplinger, Crystal M.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021
Assuntos:
Physiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8144333/
https://ncbi.nlm.nih.gov/pubmed/34045974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2021.656516
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