The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca(2+)-ATPase, is a major determinant of Ca(2+) alternans in intact mouse hearts

Sarcoplasmic reticulum (SR) Ca(2+) cycling is governed by the cardiac ryanodine receptor (RyR2) and SR Ca(2+)-ATPase (SERCA2a). Abnormal SR Ca(2+) cycling is thought to be the primary cause of Ca(2+) alternans that can elicit ventricular arrhythmias and sudden cardiac arrest. Although alterations in...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Sun, Bo, Wei, Jinhong, Zhong, Xiaowei, Guo, Wenting, Yao, Jinjing, Wang, Ruiwu, Vallmitjana, Alexander, Benitez, Raul, Hove-Madsen, Leif, Chen, S. R. Wayne
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
Soggetti:
Molecular Bases of Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120204/
https://ncbi.nlm.nih.gov/pubmed/29986885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003760
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