Suppression of Ryanodine Receptor Function Prolongs Ca(2+) Release Refractoriness and Promotes Cardiac Alternans in Intact Hearts

Beat-to-beat alternations in the amplitude of the cytosolic Ca(2+) transient (Ca (2+) alternans) are thought to be the primary cause of cardiac alternans that can lead to cardiac arrhythmias and sudden death. Despite its important role in arrhythmogenesis, the mechanism underlying Ca (2+) alternans...

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Udgivet i:Biochem J
Main Authors: Zhong, Xiaowei, Sun, Bo, Vallmitjana, Alexander, Mi, Tao, Guo, Wenting, Ni, Mingke, Wang, Ruiwu, Guo, Ang, Duff, Henry J., Gillis, Anne M., Song, Long-Sheng, Hove-Madsen, Leif, Benitez, Raul, Chen, S.R. Wayne
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5522810/
https://ncbi.nlm.nih.gov/pubmed/27582498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BCJ20160606
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