Optical Mapping of Sarcoplasmic Reticulum Ca(2+) in the Intact Heart: Ryanodine Receptor Refractoriness During Alternans and Fibrillation

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• Optical Mapping of Intra-Sarcoplasmic Reticulum Ca(2+) and Transmembrane Potential in the Langendorff-perfused Rabbit Heart
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• The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca(2+)-ATPase, is a major determinant of Ca(2+) alternans in intact mouse hearts
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• Refractoriness of sarcoplasmic reticulum Ca(2+) release determines Ca(2+) alternans in atrial myocytes
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