HITS-CLIP and integrative modeling define the Rbfox splicing-regulatory network linked to brain development and autism

SUMMARY: The RNA-binding proteins Rbfox1/2/3 regulate alternative splicing in the nervous system, and disruption of Rbfox1 has been implicated in autism. However, comprehensive identification of functional Rbfox targets has been challenging. Here we performed HITS-CLIP for all three Rbfox family mem...

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Main Authors: Weyn-Vanhentenryck, Sebastien M, Mele, Aldo, Yan, Qinghong, Sun, Shuying, Farny, Natalie, Zhang, Zuo, Xue, Chenghai, Herre, Margaret, Silver, Pamela A, Zhang, Michael Q, Krainer, Adrian R, Darnell, Robert B, Zhang, Chaolin
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992522/
https://ncbi.nlm.nih.gov/pubmed/24613350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.02.005
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