Long-Term Reduction of Cocaine Self-Administration in Rats Treated with Adenoviral Vector-Delivered Cocaine Hydrolase: Evidence for Enzymatic Activity

A new pharmacokinetic approach treating cocaine addiction involves rapidly metabolizing cocaine before it reaches brain reward centers using mutated human butyrylcholinesterase (BChE) or cocaine hydrolase (CocH). Recent work has shown that helper-dependent adenoviral (hdAD) vector-mediated plasma Co...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Zlebnik, Natalie E, Brimijoin, Stephen, Gao, Yang, Saykao, Amy T, Parks, Robin J, Carroll, Marilyn E
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2014
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988560/
https://ncbi.nlm.nih.gov/pubmed/24407266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.3
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