Combined Cocaine Hydrolase Gene Transfer and Anti-Cocaine Vaccine Synergistically Block Cocaine-Induced Locomotion

Mice and rats were tested for reduced sensitivity to cocaine-induced hyper-locomotion after pretreatment with anti-cocaine antibody or cocaine hydrolase (CocH) derived from human butyrylcholinesterase (BChE). In Balb/c mice, direct i.p. injection of CocH protein (1 mg/kg) had no effect on spontaneou...

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Detalhes bibliográficos
Main Authors: Carroll, Marilyn E., Zlebnik, Natalie E., Anker, Justin J., Kosten, Thomas R., Orson, Frank M., Shen, Xiaoyun, Kinsey, Berma, Parks, Robin J., Gao, Yang, Brimijoin, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422258/
https://ncbi.nlm.nih.gov/pubmed/22912888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043536
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