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Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months
BACKGROUND: Cocaine dependence is a pervasive disorder with high rates of relapse. In a previous study, direct administration of a quadruple mutant albumin-fused butyrylcholinesterase (BChE) that efficiently catalyzes hydrolysis of cocaine to benzoic acid and ecgonine methyl ester acutely blocked co...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3314110/ https://ncbi.nlm.nih.gov/pubmed/22209637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2011.11.014 |
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