Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months

BACKGROUND: Cocaine dependence is a pervasive disorder with high rates of relapse. In a previous study, direct administration of a quadruple mutant albumin-fused butyrylcholinesterase (BChE) that efficiently catalyzes hydrolysis of cocaine to benzoic acid and ecgonine methyl ester acutely blocked co...

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Main Authors: Anker, Justin J., Brimijoin, Stephen, Gao, Yang, Geng, Liyi, Zlebnik, Natalie E., Parks, Robin J., Carroll, Marilyn E.
格式: Artigo
語言:Inglês
出版: 2011
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314110/
https://ncbi.nlm.nih.gov/pubmed/22209637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2011.11.014
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