Long-Term Reduction of Cocaine Self-Administration in Rats Treated with Adenoviral Vector-Delivered Cocaine Hydrolase: Evidence for Enzymatic Activity

A new pharmacokinetic approach treating cocaine addiction involves rapidly metabolizing cocaine before it reaches brain reward centers using mutated human butyrylcholinesterase (BChE) or cocaine hydrolase (CocH). Recent work has shown that helper-dependent adenoviral (hdAD) vector-mediated plasma Co...

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Autors principals: Zlebnik, Natalie E, Brimijoin, Stephen, Gao, Yang, Saykao, Amy T, Parks, Robin J, Carroll, Marilyn E
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988560/
https://ncbi.nlm.nih.gov/pubmed/24407266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.3
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