Long-Term Reduction of Cocaine Self-Administration in Rats Treated with Adenoviral Vector-Delivered Cocaine Hydrolase: Evidence for Enzymatic Activity

A new pharmacokinetic approach treating cocaine addiction involves rapidly metabolizing cocaine before it reaches brain reward centers using mutated human butyrylcholinesterase (BChE) or cocaine hydrolase (CocH). Recent work has shown that helper-dependent adenoviral (hdAD) vector-mediated plasma Co...

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Hlavní autoři: Zlebnik, Natalie E, Brimijoin, Stephen, Gao, Yang, Saykao, Amy T, Parks, Robin J, Carroll, Marilyn E
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2014
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3988560/
https://ncbi.nlm.nih.gov/pubmed/24407266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.3
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