Long-Term Blockade of Cocaine Self-Administration and Locomotor Activation in Rats by an Adenoviral Vector–Delivered Cocaine Hydrolase

A promising approach in treating cocaine abuse is to metabolize cocaine in the blood using a mutated butyrylcholinesterase (BChE) that functions as a cocaine hydrolase (CocH). In rats, a helper-dependent adenoviral (hdAD) vector–mediated delivery of CocH abolished ongoing cocaine use and cocaine-pri...

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Vydáno v:J Pharmacol Exp Ther
Hlavní autoři: Smethells, John R., Swalve, Natashia, Brimijoin, Stephen, Gao, Yang, Parks, Robin J., Greer, Adam, Carroll, Marilyn E.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2016
Témata:
Behavioral Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851322/
https://ncbi.nlm.nih.gov/pubmed/26968195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.232504
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