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Long-Term Blockade of Cocaine Self-Administration and Locomotor Activation in Rats by an Adenoviral Vector–Delivered Cocaine Hydrolase
A promising approach in treating cocaine abuse is to metabolize cocaine in the blood using a mutated butyrylcholinesterase (BChE) that functions as a cocaine hydrolase (CocH). In rats, a helper-dependent adenoviral (hdAD) vector–mediated delivery of CocH abolished ongoing cocaine use and cocaine-pri...
Tallennettuna:
| Julkaisussa: | J Pharmacol Exp Ther |
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| Päätekijät: | , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The American Society for Pharmacology and Experimental Therapeutics
2016
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4851322/ https://ncbi.nlm.nih.gov/pubmed/26968195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.232504 |
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