Phosphoinositide-mediated oligomerization of a defensin induces cell lysis

Cationic antimicrobial peptides (CAPs) such as defensins are ubiquitously found innate immune molecules that often exhibit broad activity against microbial pathogens and mammalian tumor cells. Many CAPs act at the plasma membrane of cells leading to membrane destabilization and permeabilization. In...

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Main Authors: Poon, Ivan KH, Baxter, Amy A, Lay, Fung T, Mills, Grant D, Adda, Christopher G, Payne, Jennifer AE, Phan, Thanh Kha, Ryan, Gemma F, White, Julie A, Veneer, Prem K, van der Weerden, Nicole L, Anderson, Marilyn A, Kvansakul, Marc, Hulett, Mark D
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2014
Teme:
Biophysics and Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3968744/
https://ncbi.nlm.nih.gov/pubmed/24692446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01808
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