Phosphoinositide-mediated oligomerization of a defensin induces cell lysis

Cationic antimicrobial peptides (CAPs) such as defensins are ubiquitously found innate immune molecules that often exhibit broad activity against microbial pathogens and mammalian tumor cells. Many CAPs act at the plasma membrane of cells leading to membrane destabilization and permeabilization. In...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Poon, Ivan KH, Baxter, Amy A, Lay, Fung T, Mills, Grant D, Adda, Christopher G, Payne, Jennifer AE, Phan, Thanh Kha, Ryan, Gemma F, White, Julie A, Veneer, Prem K, van der Weerden, Nicole L, Anderson, Marilyn A, Kvansakul, Marc, Hulett, Mark D
פורמט: Artigo
שפה:Inglês
יצא לאור: eLife Sciences Publications, Ltd 2014
נושאים:
Biophysics and Structural Biology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3968744/
https://ncbi.nlm.nih.gov/pubmed/24692446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01808
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