Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin–lipid oligomeric assemblies and membrane permeabilization

Defensins are cationic antimicrobial peptides that serve as important components of host innate immune defenses, often by targeting cell membranes of pathogens. Oligomerization of defensins has been linked to their antimicrobial activity; however, the molecular basis underpinning this process remain...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kvansakul, Marc, Lay, Fung T., Adda, Christopher G., Veneer, Prem K., Baxter, Amy A., Phan, Thanh Kha, Poon, Ivan K. H., Hulett, Mark D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056070/
https://ncbi.nlm.nih.gov/pubmed/27647905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607855113
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