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Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin–lipid oligomeric assemblies and membrane permeabilization

Defensins are cationic antimicrobial peptides that serve as important components of host innate immune defenses, often by targeting cell membranes of pathogens. Oligomerization of defensins has been linked to their antimicrobial activity; however, the molecular basis underpinning this process remain...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Kvansakul, Marc, Lay, Fung T., Adda, Christopher G., Veneer, Prem K., Baxter, Amy A., Phan, Thanh Kha, Poon, Ivan K. H., Hulett, Mark D.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056070/
https://ncbi.nlm.nih.gov/pubmed/27647905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607855113
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