Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin–lipid oligomeric assemblies and membrane permeabilization

Defensins are cationic antimicrobial peptides that serve as important components of host innate immune defenses, often by targeting cell membranes of pathogens. Oligomerization of defensins has been linked to their antimicrobial activity; however, the molecular basis underpinning this process remain...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Kvansakul, Marc, Lay, Fung T., Adda, Christopher G., Veneer, Prem K., Baxter, Amy A., Phan, Thanh Kha, Poon, Ivan K. H., Hulett, Mark D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2016
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056070/
https://ncbi.nlm.nih.gov/pubmed/27647905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607855113
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