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Binding of phosphatidic acid by NsD7 mediates the formation of helical defensin–lipid oligomeric assemblies and membrane permeabilization

Defensins are cationic antimicrobial peptides that serve as important components of host innate immune defenses, often by targeting cell membranes of pathogens. Oligomerization of defensins has been linked to their antimicrobial activity; however, the molecular basis underpinning this process remain...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Kvansakul, Marc, Lay, Fung T., Adda, Christopher G., Veneer, Prem K., Baxter, Amy A., Phan, Thanh Kha, Poon, Ivan K. H., Hulett, Mark D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056070/
https://ncbi.nlm.nih.gov/pubmed/27647905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1607855113
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