Complementation analysis of mutants of nitric oxide synthase reveals that the active site requires two hemes.

For catalytic activity, nitric oxide synthases (NOSs) must be dimeric. Previous work revealed that the requirements for stable dimerization included binding of tetrahydrobiopterin (BH4), arginine, and heme. Here we asked what function is served by dimerization. We assessed the ability of individuall...

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Bibliografiska uppgifter
Huvudupphovsmän: Xie, Q W, Leung, M, Fuortes, M, Sassa, S, Nathan, C
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1996
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC39375/
https://ncbi.nlm.nih.gov/pubmed/8643499
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