Complementation analysis of mutants of nitric oxide synthase reveals that the active site requires two hemes.

For catalytic activity, nitric oxide synthases (NOSs) must be dimeric. Previous work revealed that the requirements for stable dimerization included binding of tetrahydrobiopterin (BH4), arginine, and heme. Here we asked what function is served by dimerization. We assessed the ability of individuall...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Xie, Q W, Leung, M, Fuortes, M, Sassa, S, Nathan, C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39375/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8643499/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.10.4891
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!