Complementation analysis of mutants of nitric oxide synthase reveals that the active site requires two hemes.
For catalytic activity, nitric oxide synthases (NOSs) must be dimeric. Previous work revealed that the requirements for stable dimerization included binding of tetrahydrobiopterin (BH4), arginine, and heme. Here we asked what function is served by dimerization. We assessed the ability of individuall...
Tallennettuna:
| Julkaisussa: | Proc Natl Acad Sci U S A |
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| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
National Academy of Sciences
1996
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39375/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8643499/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.10.4891 |
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