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Fast Ferrous Heme-NO Oxidation in Nitric Oxide Synthases

During catalysis, the heme in nitric oxide synthase (NOS) binds NO before releasing it to the environment. Oxidation of the NOS ferrous heme-NO complex by O(2) is key for catalytic cycling, but the mechanism is unclear. We utilized stopped-flow methods to study reaction of O(2) with ferrous heme-NO...

詳細記述

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書誌詳細
主要な著者: Tejero, Jesús, Santolini, Jérôme, Stuehr, Dennis J.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737443/
https://ncbi.nlm.nih.gov/pubmed/19691141
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