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Mechanism and regulation of ferrous heme-nitric oxide (NO) oxidation in NO synthases

Nitric oxide (NO) synthases (NOSs) catalyze the formation of NO from l-arginine. We have shown previously that the NOS enzyme catalytic cycle involves a large number of reactions but can be characterized by a global model with three main rate-limiting steps. These are the rate of heme reduction by t...

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Publicat a:J Biol Chem
Autors principals: Tejero, Jesús, Hunt, Andrew P., Santolini, Jérôme, Lehnert, Nicolai, Stuehr, Dennis J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514623/
https://ncbi.nlm.nih.gov/pubmed/30926606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007810
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