Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin.

Nitric oxide synthases (NOSs) require tetrahydrobiopterin (BH4) for dimerization and NO production. Mutation analysis of mouse inducible NOS (iNOS; NOS2) identified Gly-450 and Ala-453 as critical for NO production, dimer formation, and BH4 binding. Substitutions at five neighboring positions were t...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Cho, H J, Martin, E, Xie, Q W, Sassa, S, Nathan, C
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1995
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40432/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8524794/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.25.11514
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