Crystal Structures of Leukotriene C(4) Synthase in Complex with Product Analogs: IMPLICATIONS FOR THE ENZYME MECHANISM

Leukotriene (LT) C(4) synthase (LTC4S) catalyzes the conjugation of the fatty acid LTA(4) with the tripeptide GSH to produce LTC(4), the parent compound of the cysteinyl leukotrienes, important mediators of asthma. Here we mutated Trp-116 in human LTC4S, a residue proposed to play a key role in subs...

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Bibliographische Detailangaben
Hauptverfasser: Niegowski, Damian, Kleinschmidt, Thea, Olsson, Ulrika, Ahmad, Shabbir, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
Lipids
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3931076/
https://ncbi.nlm.nih.gov/pubmed/24366866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.534628
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