SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice

Our previous work has shown that gene knockout of the sodium-glucose cotransporter SGLT2 modestly lowered blood glucose in streptozotocin-diabetic mice (BG; from 470 to 300 mg/dl) and prevented glomerular hyperfiltration but did not attenuate albuminuria or renal growth and inflammation. Here we det...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Vallon, Volker, Gerasimova, Maria, Rose, Michael A., Masuda, Takahiro, Satriano, Joseph, Mayoux, Eric, Koepsell, Hermann, Thomson, Scott C., Rieg, Timo
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2013
Soggetti:
Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920018/
https://ncbi.nlm.nih.gov/pubmed/24226524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00520.2013
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi