SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice

Our previous work has shown that gene knockout of the sodium-glucose cotransporter SGLT2 modestly lowered blood glucose in streptozotocin-diabetic mice (BG; from 470 to 300 mg/dl) and prevented glomerular hyperfiltration but did not attenuate albuminuria or renal growth and inflammation. Here we det...

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Xehetasun bibliografikoak
Egile Nagusiak: Vallon, Volker, Gerasimova, Maria, Rose, Michael A., Masuda, Takahiro, Satriano, Joseph, Mayoux, Eric, Koepsell, Hermann, Thomson, Scott C., Rieg, Timo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Physiological Society 2013
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920018/
https://ncbi.nlm.nih.gov/pubmed/24226524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00520.2013
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