SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice

Our previous work has shown that gene knockout of the sodium-glucose cotransporter SGLT2 modestly lowered blood glucose in streptozotocin-diabetic mice (BG; from 470 to 300 mg/dl) and prevented glomerular hyperfiltration but did not attenuate albuminuria or renal growth and inflammation. Here we det...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Vallon, Volker, Gerasimova, Maria, Rose, Michael A., Masuda, Takahiro, Satriano, Joseph, Mayoux, Eric, Koepsell, Hermann, Thomson, Scott C., Rieg, Timo
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2013
Materias:
Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920018/
https://ncbi.nlm.nih.gov/pubmed/24226524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00520.2013
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares