Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia

In the kidney, the sodium-glucose cotransporters SGLT2 and SGLT1 are thought to account for >90 and ∼3% of fractional glucose reabsorption (FGR), respectively. However, euglycemic humans treated with an SGLT2 inhibitor maintain an FGR of 40–50%, mimicking values in Sglt2 knockout mice. Here, we s...

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Hauptverfasser: Rieg, Timo, Masuda, Takahiro, Gerasimova, Maria, Mayoux, Eric, Platt, Kenneth, Powell, David R., Thomson, Scott C., Koepsell, Hermann, Vallon, Volker
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3920019/
https://ncbi.nlm.nih.gov/pubmed/24226519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00518.2013
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