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Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus

The Na-glucose cotransporter SGLT2 mediates high-capacity glucose uptake in the early proximal tubule and SGLT2 inhibitors are developed as new antidiabetic drugs. We used gene-targeted Sglt2 knockout (Sglt2(−/−)) mice to elucidate the contribution of SGLT2 to blood glucose control, glomerular hyper...

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Главные авторы: Vallon, Volker, Rose, Michael, Gerasimova, Maria, Satriano, Joseph, Platt, Kenneth A., Koepsell, Hermann, Cunard, Robyn, Sharma, Kumar, Thomson, Scott C., Rieg, Timo
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543626/
https://ncbi.nlm.nih.gov/pubmed/23152292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00409.2012
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