Macula Densa SGLT1-NOS1-Tubuloglomerular Feedback Pathway, a New Mechanism for Glomerular Hyperfiltration during Hyperglycemia

BACKGROUND: Glomerular hyperfiltration is common in early diabetes and is considered a risk factor for later diabetic nephropathy. We propose that sodium-glucose cotransporter 1 (SGLT1) senses increases in luminal glucose at the macula densa, enhancing generation of neuronal nitric oxide synthase 1...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Zhang, Jie, Wei, Jin, Jiang, Shan, Xu, Lan, Wang, Lei, Cheng, Feng, Buggs, Jacentha, Koepsell, Hermann, Vallon, Volker, Liu, Ruisheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2019
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442354/
https://ncbi.nlm.nih.gov/pubmed/30867247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018080844
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