Knockout of Na(+)-glucose cotransporter SGLT1 mitigates diabetes-induced upregulation of nitric oxide synthase NOS1 in the macula densa and glomerular hyperfiltration

Na(+)-glucose cotransporter (SGLT)1 mediates glucose reabsorption in late proximal tubules. SGLT1 also mediates macula densa (MD) sensing of an increase in luminal glucose, which increases nitric oxide (NO) synthase 1 (MD-NOS1)-mediated NO formation and potentially glomerular filtratrion rate (GFR)....

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Veröffentlicht in:Am J Physiol Renal Physiol
Hauptverfasser: Song, Panai, Huang, Winnie, Onishi, Akira, Patel, Rohit, Kim, Young Chul, van Ginkel, Charlotte, Fu, Yiling, Freeman, Brent, Koepsell, Hermann, Thomson, Scott, Liu, Ruisheng, Vallon, Volker
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6692722/
https://ncbi.nlm.nih.gov/pubmed/31091127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00120.2019
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