Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8

The roles of microRNAs (miRNAs) and the miRNA processing machinery in the regulation of stem cell biology are not well understood. Here, we show that the p53 family member and p63 isoform, ΔNp63, is a transcriptional activator of a cofactor critical for miRNA processing (DGCR8). This regulation give...

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Autores principales: Chakravarti, Deepavali, Su, Xiaohua, Cho, Min Soon, Bui, Ngoc Hoang Bao, Coarfa, Cristian, Venkatanarayan, Avinashnarayan, Benham, Ashley L., Flores González, Ramón E., Alana, Jennifer, Xiao, Weimin, Leung, Marco L., Vin, Harina, Chan, Io Long, Aquino, Arianexys, Müller, Nicole, Wang, Hongran, Cooney, Austin J., Parker-Thornburg, Jan, Tsai, Kenneth Y., Gunaratne, Preethi H., Flores, Elsa R.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2014
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918754/
https://ncbi.nlm.nih.gov/pubmed/24449888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319743111
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