Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8

The roles of microRNAs (miRNAs) and the miRNA processing machinery in the regulation of stem cell biology are not well understood. Here, we show that the p53 family member and p63 isoform, ΔNp63, is a transcriptional activator of a cofactor critical for miRNA processing (DGCR8). This regulation give...

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Hlavní autoři: Chakravarti, Deepavali, Su, Xiaohua, Cho, Min Soon, Bui, Ngoc Hoang Bao, Coarfa, Cristian, Venkatanarayan, Avinashnarayan, Benham, Ashley L., Flores González, Ramón E., Alana, Jennifer, Xiao, Weimin, Leung, Marco L., Vin, Harina, Chan, Io Long, Aquino, Arianexys, Müller, Nicole, Wang, Hongran, Cooney, Austin J., Parker-Thornburg, Jan, Tsai, Kenneth Y., Gunaratne, Preethi H., Flores, Elsa R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2014
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3918754/
https://ncbi.nlm.nih.gov/pubmed/24449888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319743111
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