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Novel therapeutic interventions for p53-altered tumors through manipulation of its family members, p63 and p73

TP53 is highly mutated in human cancers, thus targeting this tumor suppressor pathway is highly desirable and will impact many cancer patients.(1,2) Therapeutic strategies to reactivate the p53-pathway have been challenging,(3,4) and no effective treatment exists.(5) We utilized the p53-family membe...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Venkatanarayan, Avinashnarayan, Raulji, Payal, Norton, William, Flores, Elsa R.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4825839/
https://ncbi.nlm.nih.gov/pubmed/26652033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1121333
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