ΔNp63/DGCR8-Dependent microRNAs Mediate Therapeutic Efficacy of HDAC Inhibitors in Cancer

ΔNp63 is an oncogenic member of the p53 family and acts to inhibit the tumor suppressive activities of the p53 family. By performing a chemical library screen, we identified HDAC inhibitors (HDACi) as agents reducing ΔNp63 protein stability through the E3 ubiquitin ligase, Fbw7. ΔNp63 inhibition dec...

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Vydáno v:Cancer Cell
Hlavní autoři: Napoli, Marco, Venkatanarayan, Avinashnarayan, Raulji, Payal, Meyers, Brooke A., Norton, William, Mangala, Lingegowda S., Sood, Anil K., Rodriguez-Aguayo, Cristian, Lopez-Berestein, Gabriel, Vin, Harina, Duvic, Madeleine, Tetzlaff, Michael B., Curry, Jonathan L., Rook, Alain H., Abbas, Hussein A., Coarfa, Cristian, Gunaratne, Preethi H., Tsai, Kenneth Y., Flores, Elsa R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4908836/
https://ncbi.nlm.nih.gov/pubmed/27300436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.04.016
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