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Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition
Multiple genetic variants of CARD15/NOD2 have been associated with susceptibility to Crohn's disease and Blau syndrome. NOD2 recognizes muramyl dipeptide (MDP) derived from bacterial peptidoglycan (PGN), but the molecular basis of recognition remains elusive. We performed systematic mutational...
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| 主要な著者: | , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC391079/ https://ncbi.nlm.nih.gov/pubmed/15044951 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600175 |
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