Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide

Peptidoglycan-derived muramyl dipeptide (MDP) activates innate immunity via the host sensor NOD2. Although MDP is N-acetylated in most bacteria, mycobacteria and related Actinomycetes convert their MDP to an N-glycolylated form through the action of N-acetyl muramic acid hydroxylase (NamH). We used...

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Detalhes bibliográficos
Main Authors: Coulombe, François, Divangahi, Maziar, Veyrier, Frédéric, de Léséleuc, Louis, Gleason, James L., Yang, Yibin, Kelliher, Michelle A., Pandey, Amit K., Sassetti, Christopher M., Reed, Michael B., Behr, Marcel A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
Assuntos:
Brief Definitive Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2722178/
https://ncbi.nlm.nih.gov/pubmed/19581406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20081779
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