Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

Multiple genetic variants of CARD15/NOD2 have been associated with susceptibility to Crohn's disease and Blau syndrome. NOD2 recognizes muramyl dipeptide (MDP) derived from bacterial peptidoglycan (PGN), but the molecular basis of recognition remains elusive. We performed systematic mutational...

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Main Authors: Tanabe, Tsuyoshi, Chamaillard, Mathias, Ogura, Yasunori, Zhu, Li, Qiu, Su, Masumoto, Junya, Ghosh, Partho, Moran, Anthony, Predergast, Martina M, Tromp, Gerard, Williams, Charlene J, Inohara, Naohiro, Núñez, Gabriel
格式: Artigo
語言:Inglês
出版: 2004
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC391079/
https://ncbi.nlm.nih.gov/pubmed/15044951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600175
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