Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition

Multiple genetic variants of CARD15/NOD2 have been associated with susceptibility to Crohn's disease and Blau syndrome. NOD2 recognizes muramyl dipeptide (MDP) derived from bacterial peptidoglycan (PGN), but the molecular basis of recognition remains elusive. We performed systematic mutational...

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Detalhes bibliográficos
Main Authors: Tanabe, Tsuyoshi, Chamaillard, Mathias, Ogura, Yasunori, Zhu, Li, Qiu, Su, Masumoto, Junya, Ghosh, Partho, Moran, Anthony, Predergast, Martina M, Tromp, Gerard, Williams, Charlene J, Inohara, Naohiro, Núñez, Gabriel
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC391079/
https://ncbi.nlm.nih.gov/pubmed/15044951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600175
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