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Single-molecule tracking of the transcription cycle by sub-second RNA detection

Transcription is an inherently stochastic, noisy, and multi-step process, in which fluctuations at every step can cause variations in RNA synthesis, and affect physiology and differentiation decisions in otherwise identical cells. However, it has been an experimental challenge to directly link the s...

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Hlavní autoři: Zhang, Zhengjian, Revyakin, Andrey, Grimm, Jonathan B, Lavis, Luke D, Tjian, Robert
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901038/
https://ncbi.nlm.nih.gov/pubmed/24473079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01775
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