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Single-molecule tracking of the transcription cycle by sub-second RNA detection

Transcription is an inherently stochastic, noisy, and multi-step process, in which fluctuations at every step can cause variations in RNA synthesis, and affect physiology and differentiation decisions in otherwise identical cells. However, it has been an experimental challenge to directly link the s...

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Detalhes bibliográficos
Main Authors: Zhang, Zhengjian, Revyakin, Andrey, Grimm, Jonathan B, Lavis, Luke D, Tjian, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3901038/
https://ncbi.nlm.nih.gov/pubmed/24473079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01775
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